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General anesthesia is a state of drug-induced reversible inhibition of central nervous function, during which surgical procedures can be carried out in the absence of consciousness, responsiveness to pain, defensive or involuntary movements, and significant autonomic reflex responses (A).
Compared with thioamides, its therapeutic importance is low but it is used as an adjunct in scintigraphic imaging of bone by means of technetate when accumulation in the thyroid gland has to be blocked. Short-term thyroid suppression (C). Iodine in high dosage (>6000 ?g/d) exerts a transient “thyrostatic” effect in hyperthyroid, but usually not in euthyroid, individuals.

 

Vitamin B12 is required for the conversion of methyltetrahydro- FA to tetrahydro-FA, which is important for DNA synthesis (B). Inhibition of this reaction due to B12 deficiency can be compensated by increased FA intake. The anemia is readily corrected; however, nerve degeneration progresses unchecked and its cause is made more difficult to diagnose by the absence of hematological changes.
Despite these advantageous properties, use of chloramphenicol is rarely indicated (e. g. , in CNS infections) because of the danger of bone marrow damage. Two types of bone marrow depression can occur: (1) a dose-dependent, toxic, reversible form manifested during therapy and, (2) a frequently fatal form that may occur after a latency of weeks and is not dose dependent.

 

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